IkappaB kinase
Definition:
EC Tree > 2 Transferases > 2.7 Transferring phosphorus-containing groups > 2.7.11 Protein-serine/threonine kinases > 2.7.11.10 IkappaB kinase
IkappaB kinase (IKK) is the NF-kB-activating Ser/Thr kinase. It phosphorylates IkB proteins at specific serines, releasing ADP and marking them for ubiquitination and proteasomal degradation; release of NF-kB then drives inflammation, immunity, cell proliferation and apoptosis. If the serines are replaced by threonines, activity drops sharply. Expected in Eukaryota and Bacteria.
IkappaB kinase (IKK) is the NF-kB-activating Ser/Thr kinase. It phosphorylates IkB proteins at specific serines, releasing ADP and marking them for ubiquitination and proteasomal degradation; release of NF-kB then drives inflammation, immunity, cell proliferation and apoptosis. If the serines are replaced by threonines, activity drops sharply. Expected in Eukaryota and Bacteria.
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