Insulysin
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.56 insulysin
O-sialoglycoprotein endopeptidase is a zinc metalloendopeptidase secreted by the bacterium Pasteurella haemolytica, the type example of peptidase family M22, inhibited by EDTA (100 mM) and 1,10-phenanthroline. It hydrolyzes O-sialoglycoproteins, cleaving the -Arg31-/-Asp- bond in glycophorin A, and does not cleave unglycosylated proteins, desialylated glycoproteins or N-glycosylated glycoproteins. In the pathogen it destroys host O-glycosylated surface proteins. It features an M22-family zinc catalytic fold specific for mucin-type O-glycans.
O-sialoglycoprotein endopeptidase is a zinc metalloendopeptidase secreted by the bacterium Pasteurella haemolytica, the type example of peptidase family M22, inhibited by EDTA (100 mM) and 1,10-phenanthroline. It hydrolyzes O-sialoglycoproteins, cleaving the -Arg31-/-Asp- bond in glycophorin A, and does not cleave unglycosylated proteins, desialylated glycoproteins or N-glycosylated glycoproteins. In the pathogen it destroys host O-glycosylated surface proteins. It features an M22-family zinc catalytic fold specific for mucin-type O-glycans.
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