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K562/R7

Definition:

K562/R7 is a human cancer cell line derived from Pleural effusion and associated with Blast phase chronic myelogenous leukemia, BCR-ABL1 positive and Chronic myeloid leukemia. K562/R7 is a resistant derivative of K-562 selected against Adriamycin. K562/R7 is used as an in vitro model of Blast phase chronic myelogenous leukemia, BCR-ABL1 positive and Chronic myeloid leukemia to investigate tumor-cell growth, cell survival, and pharmacological response.

References:

[1]. de Ravel MR, et al. Synthesis of new steroidal inhibitors of P-glycoprotein-mediated multidrug resistance and biological evaluation on K562/R7 erythroleukemia cells. Journal of medicinal chemistry. 2015;58(4):1832-45. [Content Brief]

[2]. Chen KG, et al. Genomic stability at the coding regions of the multidrug transporter gene ABCB1: insights into the development of alternative drug resistance mechanisms in human leukemia cells. Cancer drug resistance (Alhambra, Calif.). 2020;3(4):959-979.

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