Kanamycin kinase
Definition:
EC Tree > 2 Transferases > 2.7 Transferring phosphorus-containing groups > 2.7.1 Phosphotransferases with an alcohol group as acceptor > 2.7.1.95 kanamycin kinase
Kanamycin kinase is the aminoglycoside-resistance 3'-kinase. It phosphorylates kanamycin (and neomycin, paromomycin, neamine, paromamine, vistamycin, gentamicin A; the Pseudomonas aeruginosa enzyme also butirosin) on the 3'-hydroxyl, releasing ADP and kanamycin 3'-phosphate, inactivating the aminoglycoside. Expected in Bacteria and Eukaryota.
Kanamycin kinase is the aminoglycoside-resistance 3'-kinase. It phosphorylates kanamycin (and neomycin, paromomycin, neamine, paromamine, vistamycin, gentamicin A; the Pseudomonas aeruginosa enzyme also butirosin) on the 3'-hydroxyl, releasing ADP and kanamycin 3'-phosphate, inactivating the aminoglycoside. Expected in Bacteria and Eukaryota.
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