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KB-C2

Definition:

KB-C2 is a human cancer cell line derived from Uterus, cervix and associated with Human papillomavirus-related endocervical adenocarcinoma. KB-C2 is a resistant derivative of KB-C1.5 selected against Colchicine. KB-C2 is used as an in vitro model of Human papillomavirus-related endocervical adenocarcinoma to investigate drug resistance and membrane transport.

References:

[1]. Kitagawa S, et al. Inhibitory effects of ginsenosides and their hydrolyzed metabolites on daunorubicin transport in KB-C2 cells. Biological & pharmaceutical bulletin. 2007;30(10):1979-81.

[2]. Gao HL, et al. The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells. Frontiers in pharmacology. 2023;14:1235285.

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