KHOS-321H
Definition:
KHOS-321H is a documented misspelling of KHOS-312H caused by an ATCC catalog transfer error; KHOS-312H is a human osteosarcoma cell line derived from a right femoral bone tumor[1][2]; Cellosaurus records a homozygous CDKN2A deletion and homozygous TP53 p.Arg156Pro variant inherited from the parental line[1]. The cells have been used in osteosarcoma research, including analysis of Cbfa1/Runx2 binding and collagenase-3 promoter regulation in bone-derived tumor cells[3]. For database use, KHOS-312H should be the standard name, with KHOS-321H retained only as a documented erroneous alias and the accession CVCL_2545 included to prevent nomenclature drift.
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