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KY821

Definition:

KY821 is a human cancer cell line derived from Brain, meninges and associated with Adult acute myelomonocytic leukemia and Acute myelomonocytic leukemia. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. KY821 is used as an in vitro model of Adult acute myelomonocytic leukemia and Acute myelomonocytic leukemia to investigate tumor-cell growth, cell survival, and pharmacological response.

References:

[1]. Ariyama Y, et al. Identification of amplified DNA sequences on double minute chromosomes in a leukemic cell line KY821 by means of spectral karyotyping and comparative genomic hybridization. Journal of human genetics. 1998;43(3):187-90. [Content Brief]

[2]. Saito H, et al. A new myeloblastic leukemia cell line with double minute chromosomes. Induction of methotrexate resistance and dihydrofolate reductase gene amplification. Leukemia research. 1992;16(3):217-26.

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