L-piperazate synthase
Definition:
EC Tree > 4 Lyases > 4.8 Nitrogen-oxygen lyases > 4.8.1 Hydro-lyases > 4.8.1.1 L-piperazate synthase
L-Piperazate synthase contains heme b. Characterized from Kutzneria sp. 744, it is one of very few enzymes known to form an N-N bond: it converts N5-hydroxy-L-ornithine into (3S)-1,2-diazinane-3-carboxylate (piperazate) and water. Piperazate is incorporated by NRPS or NRPS/PKS-hybrid pathways into secondary metabolites such as kutznerides, padanamides, himastatins and sanglifehrins. It appears in viruses and cellular organisms. Structurally it is a heme-dependent N-N bond-forming oxidase.
L-Piperazate synthase contains heme b. Characterized from Kutzneria sp. 744, it is one of very few enzymes known to form an N-N bond: it converts N5-hydroxy-L-ornithine into (3S)-1,2-diazinane-3-carboxylate (piperazate) and water. Piperazate is incorporated by NRPS or NRPS/PKS-hybrid pathways into secondary metabolites such as kutznerides, padanamides, himastatins and sanglifehrins. It appears in viruses and cellular organisms. Structurally it is a heme-dependent N-N bond-forming oxidase.
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