Legumain
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.34 Legumain
Legumain is an asparaginyl endopeptidase best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes, not inhibited by compound E-64, and the type example of peptidase family C13. It hydrolyzes proteins and small-molecule substrates at -Asn-/-Xaa- bonds, and also acts as a processing enzyme for proproteins and as a ligase in plant seed storage protein maturation. In organisms it contributes to lysosomal proteolysis, antigen processing and seed protein maturation. It features a caspase-like catalytic cysteine-histidine dyad stabilized by an unusual disulfide and pH-dependent zymogen activation.
Legumain is an asparaginyl endopeptidase best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes, not inhibited by compound E-64, and the type example of peptidase family C13. It hydrolyzes proteins and small-molecule substrates at -Asn-/-Xaa- bonds, and also acts as a processing enzyme for proproteins and as a ligase in plant seed storage protein maturation. In organisms it contributes to lysosomal proteolysis, antigen processing and seed protein maturation. It features a caspase-like catalytic cysteine-histidine dyad stabilized by an unusual disulfide and pH-dependent zymogen activation.
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
