Lipoyl synthase
Definition:
EC Tree > 2 Transferases > 2.8 Transferring sulfur-containing groups > 2.8.1 Sulfurtransferases > 2.8.1.8 lipoyl synthase
Lipoyl synthase is the radical-SAM enzyme that installs the lipoyl cofactor. It carries two [4Fe-4S] clusters and, using two AdoMet molecules, abstracts H from C6 and C8 of the octanoyl chain on the lipoyl-domain lysine; radicals interact with sulfur atoms from the auxiliary cluster, forming two C-S bonds on (R)-lipoate. The auxiliary cluster is sacrificed and regenerated by Isc/Suf. Lipoylation activates pyruvate/2-oxoglutarate/branched-chain dehydrogenase E2 domains and glycine-cleavage H protein; an alternative pathway uses EC 6.3.1.20 lipoate ligase. It occurs in viruses and cellular organisms.
Lipoyl synthase is the radical-SAM enzyme that installs the lipoyl cofactor. It carries two [4Fe-4S] clusters and, using two AdoMet molecules, abstracts H from C6 and C8 of the octanoyl chain on the lipoyl-domain lysine; radicals interact with sulfur atoms from the auxiliary cluster, forming two C-S bonds on (R)-lipoate. The auxiliary cluster is sacrificed and regenerated by Isc/Suf. Lipoylation activates pyruvate/2-oxoglutarate/branched-chain dehydrogenase E2 domains and glycine-cleavage H protein; an alternative pathway uses EC 6.3.1.20 lipoate ligase. It occurs in viruses and cellular organisms.
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
