Memapsin 2
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.23 Aspartic endopeptidases > 3.4.23.46 memapsin 2
Memapsin 2 is the major beta-secretase proposed to cleave beta-amyloid precursor protein, generating the amyloidogenic beta-peptide implicated in Alzheimer's disease. It belongs to peptidase family A1 but is atypical in carrying a C-terminal membrane-spanning domain. It shows broad endopeptidase specificity and cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of amyloid precursor protein. In neurons it initiates amyloid plaque formation and is a leading Alzheimer's drug target. It features a pepsin-like catalytic ectodomain, a transmembrane anchor and a short cytoplasmic tail.
Memapsin 2 is the major beta-secretase proposed to cleave beta-amyloid precursor protein, generating the amyloidogenic beta-peptide implicated in Alzheimer's disease. It belongs to peptidase family A1 but is atypical in carrying a C-terminal membrane-spanning domain. It shows broad endopeptidase specificity and cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of amyloid precursor protein. In neurons it initiates amyloid plaque formation and is a leading Alzheimer's drug target. It features a pepsin-like catalytic ectodomain, a transmembrane anchor and a short cytoplasmic tail.
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
