Meprin A
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.18 meprin A
Procollagen C-endopeptidase is a 100-kDa zinc metalloendopeptidase in peptidase family M12 (astacin family), activity enhanced by Ca2+ and an enhancer glycoprotein. It cleaves the C-terminal propeptide at Ala-/-Asp in type I and II procollagens and at Arg-/-Asp in type III. In connective tissue it trims the C-telopeptide after N-propeptide removal to permit collagen fibril assembly. It features an astacin-like catalytic domain regulated by the type II procollagen C-proteinase enhancer.
Procollagen C-endopeptidase is a 100-kDa zinc metalloendopeptidase in peptidase family M12 (astacin family), activity enhanced by Ca2+ and an enhancer glycoprotein. It cleaves the C-terminal propeptide at Ala-/-Asp in type I and II procollagens and at Arg-/-Asp in type III. In connective tissue it trims the C-telopeptide after N-propeptide removal to permit collagen fibril assembly. It features an astacin-like catalytic domain regulated by the type II procollagen C-proteinase enhancer.
References:
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