Methionine synthase
Definition:
EC Tree > 2 Transferases > 2.1 Transferring one-carbon groups > 2.1.1 Methyltransferases > 2.1.1.13 methionine synthase
Methionine synthase contains zinc and cobalamin and remethylates homocysteine to methionine using the methyl group of 5-methyltetrahydrofolate, regenerating tetrahydrofolate; the Co(I) is occasionally oxidized to Co(II) during the cycle, and reductive reactivation uses SAM and a reducing system (NADPH and methionine synthase reductase in mammals).
Methionine synthase contains zinc and cobalamin and remethylates homocysteine to methionine using the methyl group of 5-methyltetrahydrofolate, regenerating tetrahydrofolate; the Co(I) is occasionally oxidized to Co(II) during the cycle, and reductive reactivation uses SAM and a reducing system (NADPH and methionine synthase reductase in mammals).
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