Methylecgonone reductase
Definition:
EC Tree > 1 Oxidoreductases > 1.1 Acting on the CH-OH group of donors > 1.1.1 With NAD+ or NADP+ as acceptor > 1.1.1.334 methylecgonone reductase
Methylecgonone reductase, from the coca plant Erythroxylum coca, catalyzes the penultimate step in cocaine biosynthesis, reducing ecgonone methyl ester to ecgonine methyl ester; in vivo the reaction proceeds toward this reduction, and with NADH instead of NADPH the rate drops to 14%.
Methylecgonone reductase, from the coca plant Erythroxylum coca, catalyzes the penultimate step in cocaine biosynthesis, reducing ecgonone methyl ester to ecgonine methyl ester; in vivo the reaction proceeds toward this reduction, and with NADH instead of NADPH the rate drops to 14%.
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