Microsomal epoxide hydrolase
Definition:
EC Tree > 3 Hydrolases > 3.3 Acting on ether bonds > 3.3.2 Ether hydrolases > 3.3.2.9 microsomal epoxide hydrolase
Microsomal epoxide hydrolase is a key hepatic enzyme that catalyses hydrolytic ring opening of oxiranes (epoxides) and oxetanes to the corresponding diols, involved in metabolism of numerous substrates including stereoselective ring opening of 7-oxabicyclo[4.1.0]hepta-2,4-dienes (arene oxides) to trans-dihydrodiols; the reaction proceeds via a catalytic triad and a hydroxyalkyl-enzyme intermediate. It is one of the five vertebrate epoxide hydrolases, and representative reactions are cis-stilbene oxide plus water into (1R,2R)-1,2-diphenylethane-1,2-diol and ring opening of the oxetane drug. By detoxifying reactive arene oxides it protects the liver from electrophilic xenobiotic metabolites. It is distributed across Eukaryota and Bacteria.
Microsomal epoxide hydrolase is a key hepatic enzyme that catalyses hydrolytic ring opening of oxiranes (epoxides) and oxetanes to the corresponding diols, involved in metabolism of numerous substrates including stereoselective ring opening of 7-oxabicyclo[4.1.0]hepta-2,4-dienes (arene oxides) to trans-dihydrodiols; the reaction proceeds via a catalytic triad and a hydroxyalkyl-enzyme intermediate. It is one of the five vertebrate epoxide hydrolases, and representative reactions are cis-stilbene oxide plus water into (1R,2R)-1,2-diphenylethane-1,2-diol and ring opening of the oxetane drug. By detoxifying reactive arene oxides it protects the liver from electrophilic xenobiotic metabolites. It is distributed across Eukaryota and Bacteria.
References:
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