Neprilysin-2
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.B14 neprilysin-2
PHEX peptidase is a membrane-anchored zinc metalloendopeptidase in the M13 family, found in viruses and cellular organisms. It performs proteolytic degradation of phosphaturic peptides such as FGF23; mutations cause X-linked hypophosphatemic rickets. In bone it regulates phosphate homeostasis. It features an M13-family zinc catalytic ectodomain.
PHEX peptidase is a membrane-anchored zinc metalloendopeptidase in the M13 family, found in viruses and cellular organisms. It performs proteolytic degradation of phosphaturic peptides such as FGF23; mutations cause X-linked hypophosphatemic rickets. In bone it regulates phosphate homeostasis. It features an M13-family zinc catalytic ectodomain.
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