Norspermine synthase
Definition:
EC Tree > 2 Transferases > 2.5 Transferring alkyl or aryl groups, other than methyl groups > 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) > 2.5.1.126 norspermine synthase
Norspermine synthase is an aminopropyltransferase characterized from the thermophilic archaeon Pyrobaculum aerophilum. It transfers an aminopropyl group from S-adenosyl 3-(methylsulfanyl)propylamine onto norspermidine, releasing S-methyl-5'-thioadenosine and producing norspermine. It can also synthesize norspermidine from propane-1,3-diamine and thermospermine from spermidine, both with lower activity. The long-chain polyamines stabilize double-stranded DNA at high temperatures. Unlike EC 2.5.1.127, this enzyme does not accept norspermine as substrate.
Norspermine synthase is an aminopropyltransferase characterized from the thermophilic archaeon Pyrobaculum aerophilum. It transfers an aminopropyl group from S-adenosyl 3-(methylsulfanyl)propylamine onto norspermidine, releasing S-methyl-5'-thioadenosine and producing norspermine. It can also synthesize norspermidine from propane-1,3-diamine and thermospermine from spermidine, both with lower activity. The long-chain polyamines stabilize double-stranded DNA at high temperatures. Unlike EC 2.5.1.127, this enzyme does not accept norspermine as substrate.
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