O-antigen ligase
Definition:
EC Tree > 2 Transferases > 2.4 Glycosyltransferases > 2.4.99 Transferring other glycosyl groups > 2.4.99.26 O-antigen ligase
O-antigen ligase is a Gram-negative bacterial membrane enzyme that attaches the polymerized O-antigen molecule to the outer-core region of the lipid A-core oligosaccharide, finalizing lipopolysaccharide biosynthesis. Prior to the reaction both substrates are presented at the periplasmic face of the inner membrane, and the enzyme transfers the O antigen from its polyprenyl diphosphate membrane anchor onto the lipid A-core oligosaccharide, producing a lipopolysaccharide and releasing a polyisoprenyl diphosphate. It is required for assembly of the full-length LPS in the outer membrane.
O-antigen ligase is a Gram-negative bacterial membrane enzyme that attaches the polymerized O-antigen molecule to the outer-core region of the lipid A-core oligosaccharide, finalizing lipopolysaccharide biosynthesis. Prior to the reaction both substrates are presented at the periplasmic face of the inner membrane, and the enzyme transfers the O antigen from its polyprenyl diphosphate membrane anchor onto the lipid A-core oligosaccharide, producing a lipopolysaccharide and releasing a polyisoprenyl diphosphate. It is required for assembly of the full-length LPS in the outer membrane.
References:
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