Ophiolysin

Definition:

EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.51 ophiolysin
Trimerelysin I is a 60-kDa hemorrhagic zinc metalloendopeptidase of pI 4.4 from habu snake (Trimeresurus flavoviridis, now Protobothrops flavoviridis) venom, in peptidase family M12. It cleaves only two bonds in the insulin B chain: His10-/-Leu and Ala14-/-Leu. In venom it causes hemorrhage. It features an M12-family zinc catalytic domain.

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