Pepsin A
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.23 Aspartic endopeptidases > 3.4.23.1 pepsin A
Pepsin A is the predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen A by limited proteolysis; human pepsin A occurs in five molecular forms and pig pepsin D is unphosphorylated pepsin A. It is the type example of peptidase family A1 and occurs in Eukaryota and Bacteria. It preferentially cleaves hydrophobic, preferably aromatic, residues at P1 and P1', hydrolyzing Phe1-/-Val, Gln4-/-His, Glu13-/-Ala, Ala14-/-Leu, Leu15-/-Tyr, Tyr16-/-Leu, Gly23-/-Phe, Phe24-/-Phe and Phe25-/-Tyr bonds in the B chain of insulin. In the stomach it initiates dietary protein digestion. It features the classic aspartic-protease two-aspartate catalytic dyad.
Pepsin A is the predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen A by limited proteolysis; human pepsin A occurs in five molecular forms and pig pepsin D is unphosphorylated pepsin A. It is the type example of peptidase family A1 and occurs in Eukaryota and Bacteria. It preferentially cleaves hydrophobic, preferably aromatic, residues at P1 and P1', hydrolyzing Phe1-/-Val, Gln4-/-His, Glu13-/-Ala, Ala14-/-Leu, Leu15-/-Tyr, Tyr16-/-Leu, Gly23-/-Phe, Phe24-/-Phe and Phe25-/-Tyr bonds in the B chain of insulin. In the stomach it initiates dietary protein digestion. It features the classic aspartic-protease two-aspartate catalytic dyad.
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