Pernisine
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.21 Serine endopeptidases > 3.4.21.B57 pernisine
Pernisine is a thiol-dependent serine peptidase found across Archaea and Bacteria, notable for its ability to digest the pathological scrapie isoform of prion protein (PrPSc) from human, bovine, deer and mouse sources. It inactivates protease-resistant prion aggregates through proteolytic cleavage. In organisms it contributes to prion protein clearance and protein homeostasis. It features a catalytic apparatus unusual for combining serine-peptidase activity with thiol dependence.
Pernisine is a thiol-dependent serine peptidase found across Archaea and Bacteria, notable for its ability to digest the pathological scrapie isoform of prion protein (PrPSc) from human, bovine, deer and mouse sources. It inactivates protease-resistant prion aggregates through proteolytic cleavage. In organisms it contributes to prion protein clearance and protein homeostasis. It features a catalytic apparatus unusual for combining serine-peptidase activity with thiol dependence.
References:
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