Phosphatidate phosphatase
Definition:
EC Tree > 3 Hydrolases > 3.1 Acting on ester bonds > 3.1.3 Phosphoric-monoester hydrolases > 3.1.3.4 phosphatidate phosphatase
Phosphatidate phosphatase is a Mg2+-dependent lipid phosphatase that catalyses the dephosphorylation of 1,2-diacylglycerol 3-phosphate (phosphatidic acid) into 1,2-diacyl-sn-glycerol (DAG) and inorganic phosphate. The DAG produced feeds both de novo triacylglycerol synthesis via the Kennedy pathway and protein kinase C signalling, placing the enzyme at a key branch point between lipid storage and lipid signalling. The mammalian isoforms are collectively known as lipins and contain a conserved HAD-like phosphatase domain together with a C-terminal lipin-specific membrane-binding region. It is distributed across Eukaryota and Bacteria.
Phosphatidate phosphatase is a Mg2+-dependent lipid phosphatase that catalyses the dephosphorylation of 1,2-diacylglycerol 3-phosphate (phosphatidic acid) into 1,2-diacyl-sn-glycerol (DAG) and inorganic phosphate. The DAG produced feeds both de novo triacylglycerol synthesis via the Kennedy pathway and protein kinase C signalling, placing the enzyme at a key branch point between lipid storage and lipid signalling. The mammalian isoforms are collectively known as lipins and contain a conserved HAD-like phosphatase domain together with a C-terminal lipin-specific membrane-binding region. It is distributed across Eukaryota and Bacteria.
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