Phosphoglycerate mutase
Definition:
EC Tree > 5 Isomerases > 5.4 Intramolecular transferases > 5.4.2 Phosphotransferases (phosphomutases) > 5.4.2.1 phosphoglycerate mutase
Phosphoglycerate mutase interconverts 3-phospho-D-glycerate and 2-phospho-D-glycerate in glycolysis; the mammalian and yeast enzymes are phosphorylated by (2R)-2,3-bisphosphoglycerate, which is itself an intermediate. With the rabbit muscle enzyme, dissociation of bisphosphate from the enzyme is much slower than overall isomerization. These enzymes also catalyse, slowly, the reactions of EC 5.4.2.4 bisphosphoglycerate mutase. Structurally it is a cofactor-dependent phosphoglycerate mutase.
Phosphoglycerate mutase interconverts 3-phospho-D-glycerate and 2-phospho-D-glycerate in glycolysis; the mammalian and yeast enzymes are phosphorylated by (2R)-2,3-bisphosphoglycerate, which is itself an intermediate. With the rabbit muscle enzyme, dissociation of bisphosphate from the enzyme is much slower than overall isomerization. These enzymes also catalyse, slowly, the reactions of EC 5.4.2.4 bisphosphoglycerate mutase. Structurally it is a cofactor-dependent phosphoglycerate mutase.
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