Phospholipase C
Definition:
EC Tree > 3 Hydrolases > 3.1 Acting on ester bonds > 3.1.4 Phosphoric-diester hydrolases > 3.1.4.3 phospholipase C
Phospholipase C is a phosphodiesterase that hydrolyses a phosphatidylcholine into 1,2-diacyl-sn-glycerol and phosphocholine, and also acts on other phosphatidyl esters; the bacterial zinc-containing enzyme additionally acts on sphingomyelin and phosphatidylinositol, whereas the seminal-plasma form does not act on phosphatidylinositol. By generating diacylglycerol and soluble headgroup phosphomonoesters it transduces receptor signals into protein kinase C activation and calcium mobilisation, and bacterial PLC variants act as tissue-damaging virulence factors. It is distributed across Bacteria, Eukaryota and Archaea and contains a TIM-barrel catalytic domain with coordinated Zn2+.
Phospholipase C is a phosphodiesterase that hydrolyses a phosphatidylcholine into 1,2-diacyl-sn-glycerol and phosphocholine, and also acts on other phosphatidyl esters; the bacterial zinc-containing enzyme additionally acts on sphingomyelin and phosphatidylinositol, whereas the seminal-plasma form does not act on phosphatidylinositol. By generating diacylglycerol and soluble headgroup phosphomonoesters it transduces receptor signals into protein kinase C activation and calcium mobilisation, and bacterial PLC variants act as tissue-damaging virulence factors. It is distributed across Bacteria, Eukaryota and Archaea and contains a TIM-barrel catalytic domain with coordinated Zn2+.
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