Phosphonoacetaldehyde hydrolase
Definition:
EC Tree > 3 Hydrolases > 3.11 Acting on carbon-phosphorus bonds > 3.11.1 Acting on carbon-phosphorus bonds (only sub-subclass identified to date) > 3.11.1.1 phosphonoacetaldehyde hydrolase
Phosphonoacetaldehyde hydrolase is a C-P bond-cleaving enzyme that hydrolyses phosphonoacetaldehyde into acetaldehyde and phosphate; it destabilises the otherwise stable C-P bond by forming a Schiff-base imine between an active-site lysine and the carbonyl of the substrate, in a mechanism analogous to the C-C bond cleavage of fructose-bisphosphate aldolase (EC 4.1.2.13), and belongs to the haloacetate dehalogenase family. By breaking the C-P bond it allows bacteria and eukaryotes to use phosphonates as a phosphorus source. It is distributed across Bacteria and Eukaryota.
Phosphonoacetaldehyde hydrolase is a C-P bond-cleaving enzyme that hydrolyses phosphonoacetaldehyde into acetaldehyde and phosphate; it destabilises the otherwise stable C-P bond by forming a Schiff-base imine between an active-site lysine and the carbonyl of the substrate, in a mechanism analogous to the C-C bond cleavage of fructose-bisphosphate aldolase (EC 4.1.2.13), and belongs to the haloacetate dehalogenase family. By breaking the C-P bond it allows bacteria and eukaryotes to use phosphonates as a phosphorus source. It is distributed across Bacteria and Eukaryota.
References:
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