Plasmepsin IV
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.23 Aspartic endopeptidases > 3.4.23.B14 plasmepsin IV
Plasmepsin IV is a Plasmodium aspartic endopeptidase that cleaves hemoglobin. In the S3 and S2 subsites, plasmepsin-4 orthologs all prefer hydrophobic residues Phe or Ile and reject charged residues such as Lys or Asp; in S2' and S3' they tolerate both hydrophobic and hydrophilic residues. In the parasite food vacuole it contributes to hemoglobin digestion. It features a pepsin-like aspartic-protease fold.
Plasmepsin IV is a Plasmodium aspartic endopeptidase that cleaves hemoglobin. In the S3 and S2 subsites, plasmepsin-4 orthologs all prefer hydrophobic residues Phe or Ile and reject charged residues such as Lys or Asp; in S2' and S3' they tolerate both hydrophobic and hydrophilic residues. In the parasite food vacuole it contributes to hemoglobin digestion. It features a pepsin-like aspartic-protease fold.
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