Plasminogen activator Pla
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.23 Aspartic endopeptidases > 3.4.23.48 plasminogen activator Pla
Plasminogen activator Pla is an aspartic protease in peptidase family A26 from the plague bacterium Yersinia pestis. It converts human Glu-plasminogen to plasmin by cleaving the Arg560-/-Val bond also hydrolyzed by mammalian u-PA and t-PA, and additionally cleaves arginyl bonds in other proteins. In the pathogen it dissolves host fibrin and promotes tissue invasion and dissemination. It features an outer-membrane aspartic-protease fold.
Plasminogen activator Pla is an aspartic protease in peptidase family A26 from the plague bacterium Yersinia pestis. It converts human Glu-plasminogen to plasmin by cleaving the Arg560-/-Val bond also hydrolyzed by mammalian u-PA and t-PA, and additionally cleaves arginyl bonds in other proteins. In the pathogen it dissolves host fibrin and promotes tissue invasion and dissemination. It features an outer-membrane aspartic-protease fold.
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