Polyglycylase
Definition:
EC Tree > 6 Ligases > 6.3 Forming carbon-nitrogen bonds > 6.3.2 Acid—amino-acid ligases (peptide synthases) > 6.3.2.B4 polyglycylase
Polyglycylase adds glycine residues to the C-terminal tails of tubulin and other substrates: ATP plus α-tubulin plus glycine yields glycyl-α-tubulin plus ADP plus phosphate. It is a post-translational modification enzyme found in viruses and cellular organisms. Structurally it is an ATP-grasp glycylase.
Polyglycylase adds glycine residues to the C-terminal tails of tubulin and other substrates: ATP plus α-tubulin plus glycine yields glycyl-α-tubulin plus ADP plus phosphate. It is a post-translational modification enzyme found in viruses and cellular organisms. Structurally it is an ATP-grasp glycylase.
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