Proline 3-hydroxylase
Definition:
EC Tree > 1 Oxidoreductases > 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen > 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor > 1.14.11.28 proline 3-hydroxylase
Proline 3-hydroxylase is an Fe(II)-requiring 2-oxoglutarate oxygenase; unlike collagen-proline hydroxylases (EC 1.14.11.2 and EC 1.14.11.7) it does not require ascorbate, though ascorbate stimulates activity. It hydroxylates L-proline at C3 to cis-3-hydroxy-L-proline, consuming 2-oxoglutarate and O2 and releasing succinate and CO2.
Proline 3-hydroxylase is an Fe(II)-requiring 2-oxoglutarate oxygenase; unlike collagen-proline hydroxylases (EC 1.14.11.2 and EC 1.14.11.7) it does not require ascorbate, though ascorbate stimulates activity. It hydroxylates L-proline at C3 to cis-3-hydroxy-L-proline, consuming 2-oxoglutarate and O2 and releasing succinate and CO2.
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