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Proprotein convertase 4

Definition:

EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.21 Serine endopeptidases > 3.4.21.B24 proprotein convertase 4
Proprotein convertase 4 is a sperm/ovary subtilisin-like proprotein convertase that cleaves hormones at pairs of basic amino-acid residues. By processing reproductive prohormones it supports gamete function. It appears in viruses and cellular organisms.

References:

[1]. Basak A., et al. Enzymic characterization in vitro of recombinant proprotein convertase PC4 (1999), Biochem. J. , 343, 29-37.

[2]. Basak A., et al. Enediynyl peptides and iso-coumarinyl methyl sulfones as inhibitors of proprotein convertases PCSK8/SKI-1/S1P and PCSK4/PC4 Design, synthesis and biological evaluations (2015), Bioorg. Med. Chem. Lett. , 25, 2225-2237 .

[3]. Gordon V.M., et al. A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen (1997), Infect. Immun. , 65, 3370-3375.

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