Pseudaminic acid synthase
Definition:
EC Tree > 2 Transferases > 2.5 Transferring alkyl or aryl groups, other than methyl groups > 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) > 2.5.1.97 pseudaminic acid synthase
Pseudaminic acid synthase is a bacterial sialic-acid-like nonulosonic acid biosynthetic enzyme requiring a divalent metal (highest activity with Mn2+ and Co2+). It condenses phosphoenolpyruvate with 2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose and water, releasing phosphate and forming 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid (pseudaminic acid), the sugar decorating bacterial flagellins and pili. It occurs in viruses and cellular organisms.
Pseudaminic acid synthase is a bacterial sialic-acid-like nonulosonic acid biosynthetic enzyme requiring a divalent metal (highest activity with Mn2+ and Co2+). It condenses phosphoenolpyruvate with 2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose and water, releasing phosphate and forming 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid (pseudaminic acid), the sugar decorating bacterial flagellins and pili. It occurs in viruses and cellular organisms.
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