Pseudouridylate synthase
Definition:
EC Tree > 4 Lyases > 4.2 Carbon-oxygen lyases > 4.2.1 Hydro-lyases > 4.2.1.70 pseudouridylate synthase
Pseudouridylate synthase is a RNA-uridine isomerase/hydratase that rearranges uridine 5'-phosphate (uracil plus ribose 5-phosphate) into pseudouridine 5'-phosphate and water. The reaction is reversible; enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate, while the E. coli enzyme functions in vivo as a pseudouridine-5'-phosphate glycosidase. It is found in Eukaryota and Bacteria. Structurally it is a pseudouridine synthase.
Pseudouridylate synthase is a RNA-uridine isomerase/hydratase that rearranges uridine 5'-phosphate (uracil plus ribose 5-phosphate) into pseudouridine 5'-phosphate and water. The reaction is reversible; enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate, while the E. coli enzyme functions in vivo as a pseudouridine-5'-phosphate glycosidase. It is found in Eukaryota and Bacteria. Structurally it is a pseudouridine synthase.
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