Ribotoxin
Definition:
EC Tree > 4 Lyases > 4.6 Phosphorus-oxygen lyases > 4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date) > 4.6.1.23 ribotoxin
Ribotoxins are rRNA endonucleases that cleave the phosphodiester bond between a specific guanosine and adenosine in 28S rRNA. The enzyme secreted by Aspergillus giganteus specifically cleaves rat 28S rRNA between G4325 and A4326 and is cytotoxic to animal cells; it can also act on bacterial rRNA. The two-step cleavage first produces 2',3'-cyclic phosphodiester fragments that are then hydrolyzed. Structurally it is a fungal ribotoxin.
Ribotoxins are rRNA endonucleases that cleave the phosphodiester bond between a specific guanosine and adenosine in 28S rRNA. The enzyme secreted by Aspergillus giganteus specifically cleaves rat 28S rRNA between G4325 and A4326 and is cytotoxic to animal cells; it can also act on bacterial rRNA. The two-step cleavage first produces 2',3'-cyclic phosphodiester fragments that are then hydrolyzed. Structurally it is a fungal ribotoxin.
References:
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