S2P endopeptidase
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.85 S2P endopeptidase
ADAM 17 endopeptidase is a membrane-anchored zinc metalloendopeptidase in peptidase family M12. In vivo it cleaves the membrane-bound 26-kDa tumor necrosis factor-alpha precursor at Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser, releasing soluble 17-kDa TNF-alpha that induces inflammation, and similarly sheds other membrane-anchored cell-surface proteins. It shows narrow endopeptidase specificity. In cells it drives inflammatory cytokine release and ectodomain shedding. It features an M12-family zinc catalytic ectodomain linked to a disintegrin domain.
ADAM 17 endopeptidase is a membrane-anchored zinc metalloendopeptidase in peptidase family M12. In vivo it cleaves the membrane-bound 26-kDa tumor necrosis factor-alpha precursor at Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser, releasing soluble 17-kDa TNF-alpha that induces inflammation, and similarly sheds other membrane-anchored cell-surface proteins. It shows narrow endopeptidase specificity. In cells it drives inflammatory cytokine release and ectodomain shedding. It features an M12-family zinc catalytic ectodomain linked to a disintegrin domain.
References:
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
