Sortase A
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.70 sortase A
Sortase A is a bacterial transpeptidase in peptidase family C60 that anchors surface proteins to the cell wall. It cleaves a sorting signal containing the LPXTG motif between Thr and Gly, and covalently attaches the resulting threonine carboxyl end of the protein to a pentaglycine cross-bridge of peptidoglycan. In Gram-positive bacteria it displays virulence factors, adhesins and immune-evasion proteins on the cell surface. It is a target for anti-virulence drugs. It features a cysteine-transpeptidase catalytic triad with a beta-barrel fold.
Sortase A is a bacterial transpeptidase in peptidase family C60 that anchors surface proteins to the cell wall. It cleaves a sorting signal containing the LPXTG motif between Thr and Gly, and covalently attaches the resulting threonine carboxyl end of the protein to a pentaglycine cross-bridge of peptidoglycan. In Gram-positive bacteria it displays virulence factors, adhesins and immune-evasion proteins on the cell surface. It is a target for anti-virulence drugs. It features a cysteine-transpeptidase catalytic triad with a beta-barrel fold.
References:
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
