Sphingosine kinase
Definition:
EC Tree > 2 Transferases > 2.7 Transferring phosphorus-containing groups > 2.7.1 Phosphotransferases with an alcohol group as acceptor > 2.7.1.91 sphingosine kinase
Sphingosine kinase is the sphingolipid-signaling kinase. It phosphorylates sphingoid long-chain bases — sphingosine, dihydrosphingosine (sphinganine), phytosphingosine, 4-hydroxy-8-sphingenine, 4,8-sphingadienine and threo-dihydrosphingosine — on the 1-hydroxyl, releasing ADP and the corresponding sphingoid base 1-phosphate (e.g. sphingosine 1-phosphate), a bioactive pro-survival and migratory second messenger. It occurs in viruses and cellular organisms.
Sphingosine kinase is the sphingolipid-signaling kinase. It phosphorylates sphingoid long-chain bases — sphingosine, dihydrosphingosine (sphinganine), phytosphingosine, 4-hydroxy-8-sphingenine, 4,8-sphingadienine and threo-dihydrosphingosine — on the 1-hydroxyl, releasing ADP and the corresponding sphingoid base 1-phosphate (e.g. sphingosine 1-phosphate), a bioactive pro-survival and migratory second messenger. It occurs in viruses and cellular organisms.
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