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Spumapepsin

Definition:

EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.23 Aspartic endopeptidases > 3.4.23.B11 spumapepsin
Spumapepsin is a foamy-virus aspartic endopeptidase found in viruses and cellular organisms, cleaving peptide bonds at Asn-Thr, Asn-Gln, Asn-Cys and Asn-Ala. In the viral life cycle it matures Gag and Pol precursors. It features a retroviral aspartic-protease fold.

References:

[1]. Fenyofalvi G., et al. Expression and characterization of human foamy virus proteinase (1999), FEBS Lett. , 462, 397-401.

[2]. Pfrepper K.I., et al. Molecular characterization of proteolytic processing of the Gag proteins of human spumavirus (1999), J. Virol. , 73, 7907-7911.

[3]. Pavlickova L., et al. 15gag proteinase of myeloblastosis-associated virus: specificity studies with substrate-based inhibitors (1992), Arch. Biochem. Biophys. , 298, 753-756.

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