Staphopain
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.48 staphopain
Staphopain is a broad-spectrum cysteine endopeptidase from Staphylococcus species and the type example of peptidase family C47. It acts broadly on proteins including elastin, but hydrolyzes small-molecule substrates rather limitedly; assays are conveniently performed with hemoglobin, casein or Z-Phe-Arg-NHMec. In the bacterium it contributes to immune evasion by degrading immunoglobulins and chemokines, and to tissue invasion. It features a catalytic papain-like fold secreted as an extracellular virulence factor.
Staphopain is a broad-spectrum cysteine endopeptidase from Staphylococcus species and the type example of peptidase family C47. It acts broadly on proteins including elastin, but hydrolyzes small-molecule substrates rather limitedly; assays are conveniently performed with hemoglobin, casein or Z-Phe-Arg-NHMec. In the bacterium it contributes to immune evasion by degrading immunoglobulins and chemokines, and to tissue invasion. It features a catalytic papain-like fold secreted as an extracellular virulence factor.
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