Ste24 endopeptidase
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.84 Ste24 endopeptidase
S2P endopeptidase is an integral membrane zinc metalloendopeptidase, the type example of peptidase family M50. The transcription factors SREBP-1 and SREBP-2 are synthesized as ER-membrane precursors and require two cleavages to release the active factor to the nucleus; this enzyme performs the second, site-2 cleavage. It cleaves type-2 transmembrane transcription factors within their membrane-spanning domains, known substrates including SREBP-1, SREBP-2 and forms of ATF6. SREBP-2 is cleaved at DRSR_ILL_483-/-CVLTFLCLSFNPLTSLLQWGGA, with the membrane-spanning segment underlined. In cells it couples cholesterol and ER-stress signals to transcription. It features an M50-family zinc catalytic site embedded in the membrane.
S2P endopeptidase is an integral membrane zinc metalloendopeptidase, the type example of peptidase family M50. The transcription factors SREBP-1 and SREBP-2 are synthesized as ER-membrane precursors and require two cleavages to release the active factor to the nucleus; this enzyme performs the second, site-2 cleavage. It cleaves type-2 transmembrane transcription factors within their membrane-spanning domains, known substrates including SREBP-1, SREBP-2 and forms of ATF6. SREBP-2 is cleaved at DRSR_ILL_483-/-CVLTFLCLSFNPLTSLLQWGGA, with the membrane-spanning segment underlined. In cells it couples cholesterol and ER-stress signals to transcription. It features an M50-family zinc catalytic site embedded in the membrane.
References:
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
