Stizolobate synthase
Definition:
EC Tree > 1 Oxidoreductases > 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) > 1.13.11 With incorporation of two atoms of oxygen > 1.13.11.29 stizolobate synthase
Stizolobate synthase is a Zn2+-requiring dioxygenase found in eukaryotes and bacteria. It cleaves L-dopa with O2 to the ring-opened 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde, which then undergoes ring closure and oxidation (with NAD(P)+ as acceptor) to stizolobic acid.
Stizolobate synthase is a Zn2+-requiring dioxygenase found in eukaryotes and bacteria. It cleaves L-dopa with O2 to the ring-opened 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde, which then undergoes ring closure and oxidation (with NAD(P)+ as acceptor) to stizolobic acid.
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