T-Plasminogen activator
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.21 Serine endopeptidases > 3.4.21.68 t-Plasminogen activator
T-Plasminogen activator (tPA, tissue-type plasminogen activator) is an endothelial-cell serine protease in family S1 (formerly EC 3.4.21.31 and EC 3.4.99.26), secreted as a single-chain precursor cleaved to two chains by plasmin, with activity greatly enhanced by fibrin; it specifically cleaves the Arg-Val bond in plasminogen to form plasmin. By activating fibrinolysis at clots it dissolves thrombi and is a major stroke drug. It appears in viruses and cellular organisms.
T-Plasminogen activator (tPA, tissue-type plasminogen activator) is an endothelial-cell serine protease in family S1 (formerly EC 3.4.21.31 and EC 3.4.99.26), secreted as a single-chain precursor cleaved to two chains by plasmin, with activity greatly enhanced by fibrin; it specifically cleaves the Arg-Val bond in plasminogen to form plasmin. By activating fibrinolysis at clots it dissolves thrombi and is a major stroke drug. It appears in viruses and cellular organisms.
References:
Biomedical Dictionary
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