T78-1
Definition:
T78-1 is a Chinese hamster Fibroblast of lung spontaneously immortalized cell line derived from Lung. Its spontaneous immortalization permits extended propagation while retaining lineage-associated properties. T78-1 is used to investigate cellular phenotype, signal transduction, and pharmacological response in a controlled cellular system.
References:
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[1]. Friedlos F, et al. Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy. Journal of medicinal chemistry. 1997;40(8):1270-5. [Content Brief]
[2]. Helsby NA, et al. 2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT. British journal of cancer. 2004;90(5):1084-92. [Content Brief]
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