Tentoxilysin
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.68 tentoxilysin
Bontoxilysin is a zinc metalloendopeptidase produced by Clostridium botulinum, occurring as forms A-G differing in specificity on the neuroexocytosis apparatus, in peptidase family M27. The 150-kDa proenzymes are processed to disulfide-linked 100- and 50-kDa subunits, the latter carrying the endopeptidase activities, and are weakly inhibited by captopril and phosphoramidon. It performs limited hydrolysis of synaptobrevin (VAMP), SNAP-25 or syntaxin, with no action on small-molecule substrates. Acting at neuromuscular junctions, it blocks acetylcholine release and causes flaccid paralysis, in contrast to the spastic paralysis of tentoxilysin. It features an M27-family zinc catalytic light chain bound to a ganglioside-binding heavy chain.
Bontoxilysin is a zinc metalloendopeptidase produced by Clostridium botulinum, occurring as forms A-G differing in specificity on the neuroexocytosis apparatus, in peptidase family M27. The 150-kDa proenzymes are processed to disulfide-linked 100- and 50-kDa subunits, the latter carrying the endopeptidase activities, and are weakly inhibited by captopril and phosphoramidon. It performs limited hydrolysis of synaptobrevin (VAMP), SNAP-25 or syntaxin, with no action on small-molecule substrates. Acting at neuromuscular junctions, it blocks acetylcholine release and causes flaccid paralysis, in contrast to the spastic paralysis of tentoxilysin. It features an M27-family zinc catalytic light chain bound to a ganglioside-binding heavy chain.
References:
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
