Thiazoline synthase
Definition:
EC Tree > 6 Ligases > 6.2 Forming carbon-sulfur bonds > 6.2.2 Amide—thiol ligases > 6.2.2.3 thiazoline synthase
Thiazoline synthase requires Mg2+. It participates in biosynthesis of some RiPP natural products such as the trunkamides, converting L-cysteine residues into thiazoline rings. It requires a YcaO cyclodehydratase domain and a substrate-recognition element (RRE) domain that controls regiospecificity; the RRE may be encoded as a standalone protein or fused to the YcaO domain. Structurally it is a YcaO/RRE cyclodehydratase.
Thiazoline synthase requires Mg2+. It participates in biosynthesis of some RiPP natural products such as the trunkamides, converting L-cysteine residues into thiazoline rings. It requires a YcaO cyclodehydratase domain and a substrate-recognition element (RRE) domain that controls regiospecificity; the RRE may be encoded as a standalone protein or fused to the YcaO domain. Structurally it is a YcaO/RRE cyclodehydratase.
References:
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