Thioglycine synthase
Definition:
EC Tree > 6 Ligases > 6.2 Forming carbon-sulfur bonds > 6.2.2 Amide—thiol ligases > 6.2.2.1 thioglycine synthase
Thioglycine synthase requires Mg2+. It is found in anaerobic methanogenic and methanotrophic archaea, where it modifies a glycine residue in EC 2.8.4.1 coenzyme-B sulfoethylthiotransferase (methyl-coenzyme M reductase). Upon substrate binding, an external sulfide source attacks the target amide bond to form a tetrahedral intermediate; the amide oxyanion then attacks the γ-phosphate of ATP, releasing ADP and phosphate and yielding the thioamide. Structurally it is an ATP-dependent thiocarboxylate-forming enzyme.
Thioglycine synthase requires Mg2+. It is found in anaerobic methanogenic and methanotrophic archaea, where it modifies a glycine residue in EC 2.8.4.1 coenzyme-B sulfoethylthiotransferase (methyl-coenzyme M reductase). Upon substrate binding, an external sulfide source attacks the target amide bond to form a tetrahedral intermediate; the amide oxyanion then attacks the γ-phosphate of ATP, releasing ADP and phosphate and yielding the thioamide. Structurally it is an ATP-dependent thiocarboxylate-forming enzyme.
References:
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
