Thymidylate synthase
Definition:
EC Tree > 2 Transferases > 2.1 Transferring one-carbon groups > 2.1.1 Methyltransferases > 2.1.1.45 thymidylate synthase
Thymidylate synthase methylates dUMP using 5,10-methylenetetrahydrofolate, converting it to dTMP and dihydrofolate; it is the sole de novo source of thymidylate in DNA biosynthesis and a major cancer-chemotherapy target.
Thymidylate synthase methylates dUMP using 5,10-methylenetetrahydrofolate, converting it to dTMP and dihydrofolate; it is the sole de novo source of thymidylate in DNA biosynthesis and a major cancer-chemotherapy target.
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