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Tryptamine 5-hydroxylase

Definition:

EC Tree > 1 Oxidoreductases > 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen > 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor > 1.14.14.186 tryptamine 5-hydroxylase
Tryptamine 5-hydroxylase is a cytochrome P-450 characterized from rice Oryza sativa and walnut Juglans regia, hydroxylating tryptamine at C5 to serotonin.

References:

[1]. Schroeder P., et al. Latest on enzymology of serotonin biosynthesis in walnut seeds (1999), Adv. Exp. Med. Biol. , 467, 637-644.

[2]. Fujiwara T., et al. Sekiguchi lesion gene encodes a cytochrome P450 monooxygenase that catalyzes conversion of tryptamine to serotonin in rice (2010), J. Biol. Chem. , 285, 11308-11313.

[3]. Park S., et al. Production of serotonin by dual expression of tryptophan decarboxylase and tryptamine 5-hydroxylase in Escherichia coli (2011), Appl. Microbiol. Biotechnol. , 89, 1387-1394.

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