Tryptophan 7-halogenase

Definition:

EC Tree > 1 Oxidoreductases > 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen > 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water > 1.14.19.9 tryptophan 7-halogenase
Tryptophan 7-halogenase from Lechevalieria aerocolonigenes is a flavin-dependent halogenase that chlorinates C7 of tryptophan in rebeccamycin biosynthesis via C4a-hydroperoxyflavin/lysine chloramine; also uses bromide (cf. C5 EC 1.14.19.58, C6 EC 1.14.19.59).

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