Tuberculosinol synthase
Definition:
EC Tree > 3 Hydrolases > 3.1 Acting on ester bonds > 3.1.7 Diphosphoric-monoester hydrolases > 3.1.7.8 tuberculosinol synthase
Tuberculosinol synthase is a mycobacterial diterpene cyclase/hydrolase found only in tuberculosis-causing Mycobacterium species, which produces tuberculosinol together with isotuberculosinol in a 1:1 mixture (cf. isotuberculosinol synthase EC 3.1.7.9). By generating the virulence-associated diterpene alcohol it contributes to mycobacterial survival in the macrophage phagosome and to tuberculosis pathogenesis.
Tuberculosinol synthase is a mycobacterial diterpene cyclase/hydrolase found only in tuberculosis-causing Mycobacterium species, which produces tuberculosinol together with isotuberculosinol in a 1:1 mixture (cf. isotuberculosinol synthase EC 3.1.7.9). By generating the virulence-associated diterpene alcohol it contributes to mycobacterial survival in the macrophage phagosome and to tuberculosis pathogenesis.
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