Ulp2 peptidase
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.22 Cysteine endopeptidases > 3.4.22.B67 Ulp2 peptidase
Ulp2 peptidase is a SUMO-specific cysteine protease found in viruses and cellular organisms. It hydrolyzes the SUMO-SUMO linkage within poly-SUMO chains and catalyzes desumoylation of SUMO-modified kinetochore proteins Ndc10, Bir1 and Cep3. In the nucleus it controls kinetochore sumoylation dynamics and chromosome segregation. It features a SENP-family cysteine-protease catalytic domain.
Ulp2 peptidase is a SUMO-specific cysteine protease found in viruses and cellular organisms. It hydrolyzes the SUMO-SUMO linkage within poly-SUMO chains and catalyzes desumoylation of SUMO-modified kinetochore proteins Ndc10, Bir1 and Cep3. In the nucleus it controls kinetochore sumoylation dynamics and chromosome segregation. It features a SENP-family cysteine-protease catalytic domain.
References:
Biomedical Dictionary
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